Limits of Knowledge

Throughout part one of Bacon's The New Organon, I was intrigued by his desire to know things in nature perfectly and this struggle with his borderline skepticism. Bacon firstly concedes that "The doctrine of those who have denied that all certainty could be attained at all, has some agreement with my way of proceeding at the first setting out" (a.37). However, he then goes on to disagree with these skeptics and argue that things can be known. But later in aphorism 48, it seems like Bacon backtracks a little by saying that "we cannot conceive of any end or limit in the world." Here, my question truly turns into, at what limit do you think that Bacon would argue one can "know" or "conceive"of something? Are there limits on knowledge for Bacon? And if so, what are those limits?